{"id":911,"date":"2024-11-09T10:48:38","date_gmt":"2024-11-09T10:48:38","guid":{"rendered":"https:\/\/nourish.pharma.hr\/?p=911"},"modified":"2025-01-11T11:59:08","modified_gmt":"2025-01-11T11:59:08","slug":"lipo-sil","status":"publish","type":"post","link":"https:\/\/nourish.pharma.hr\/hr\/projects\/lipo-sil\/","title":{"rendered":"Lipo-SIL"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"911\" class=\"elementor elementor-911\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7db92299 e-con-full animated-slow e-flex elementor-invisible e-con e-parent\" data-id=\"7db92299\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-273b5d6d e-con-full e-flex e-con e-child\" data-id=\"273b5d6d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4cfcbd90 elementor-widget elementor-widget-text-editor\" data-id=\"4cfcbd90\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Lipo-SIL<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-557e57b2 elementor-widget elementor-widget-text-editor\" data-id=\"557e57b2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><strong>TITLE:<\/strong> Innovation in the treatment of squamous intraepithelial lesions: development of multicomponent formulations based on alpha-lipoic acid with high bioavailability<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6afc4f4b elementor-widget elementor-widget-text-editor\" data-id=\"6afc4f4b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">SIL refers to a precancerous condition that causes significant concern for patients. Currently, there are no specific recommendations for non-invasive therapeutic approaches; however, more frequent check-ups are advised for patients with Low-Grade Squamous Intraepithelial Lesions (LSIL). It is generally recommended to strengthen the immune system in these cases.<\/p><p class=\"p1\">For patients with High-Grade Squamous Intraepithelial Lesions (HSIL), the recommendation is to remove the affected areas of the cervix using ablative and excisional methods.In the context of treating SIL and preventing cervical cancer, Alpha-Lipoic Acid (ALA) has emerged as a promising option. Recent clinical research indicates that ALA is a potent antioxidant and immunomodulator, particularly effective in inducing complete resolution of LSIL (Divkovi\u0107 et al., 2023; Divkovi\u0107 et al., 2022). Notably, after three months of administration at a dosage of 600 mg per day, LSIL was resolved in an impressive 95% of patients.<\/p><p class=\"p1\">However, it is important to note that the clinical effectiveness of ALA across various indications is significantly limited by its low bioavailability, which results in suboptimal therapeutic outcomes (Salehi et al., 2019; Pop et al., 2021). ALA&#8217;s poor solubility, instability under gastrointestinal conditions, and substantial metabolism in the liver contribute to its short plasma half-life and low bioavailability (approximately 30%).<\/p><p class=\"p1\">Additionally, ALA is prone to degradation when exposed to light and high temperatures. The available forms of ALA on the market also exhibit considerable variability in content and quality (Lali\u0107-Popovi\u0107 et al., 2023).Given these challenges, it is crucial to develop pharmaceutical formulations for oral administration of ALA that ensure adequate stability during storage, enhance gastrointestinal stability, and possess a clearly defined pharmacokinetic profile.<\/p><p class=\"p1\">Based on recent scientific findings, there is an emerging idea for innovative therapeutic solutions aimed at treating SIL and preventing cervical cancer. This initiative focuses on designing a multicomponent pharmaceutical preparation (MKP) based on ALA, enhanced for bioavailability and combined with nutraceuticals known for their antioxidant and\/or antiviral properties. Therefore, the research project will concentrate on the following objectives: development of an innovative advanced pharmaceutical form of ALA with satisfactory bioavailability (1); definition of the composition of MKP specifically intended for the treatment of SIL (2); formulation of MKP tailored for the treatment of SIL (3).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-714a8c22 e-con-full animated-slow e-flex elementor-invisible e-con e-parent\" data-id=\"714a8c22\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-53f166c5 e-con-full e-flex e-con e-child\" data-id=\"53f166c5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4735a276 elementor-widget elementor-widget-text-editor\" data-id=\"4735a276\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><span class=\"s1\"><strong>BUDGET:<\/strong> 29.347,09 EUR (<\/span>NPOO.C3.2.R2-I1.05; <a href=\"https:\/\/fondovieu.gov.hr\/pozivi\/56\"><span class=\"s2\">https:\/\/fondovieu.gov.hr\/pozivi\/56<\/span><\/a>)<\/p><p class=\"p3\"><strong>DURATION:<\/strong> 20.02.2024-19.02.2026<br \/><br \/><\/p><p class=\"p5\"><b>PROJECT TEAM<\/b><\/p><p class=\"p5\"><b>PROJECT LEADER:<span class=\"Apple-converted-space\">\u00a0<\/span><\/b><\/p><p class=\"p5\">Dubravka Vitali \u010cepo full professor<\/p><p class=\"p5\">University of Zagreb Faculty of Pharmacy and Biochemist<\/p><p class=\"p5\">Department of Nutrition and Dietetics<\/p><p class=\"p5\">Ante Kova\u010di\u0107a 1, 10000 Zagreb, Croatia<\/p><p class=\"p5\"><strong>Tel:<\/strong> +385 1 4960772<\/p><p class=\"p6\"><span class=\"s3\"><strong>e-mail:<\/strong> <a href=\"mailto:dubravka.vitali@pharma.unizg.hr\"><span class=\"s2\">dubravka.vitali@pharma.unizg.hr<\/span><\/a><\/span><\/p><p class=\"p5\"><b>PROJECT ASSOCIATES:<\/b><\/p><p class=\"p3\"><b>University of Zagreb Faculty of Pharmacy and Biochemistry: <\/b>Kristina Radi\u0107 PhD; Mario Jug full professor; Karolina Miljak Mpharm.<br \/><br \/><\/p><p class=\"p5\"><span style=\"text-decoration: underline;\"><b>PUBLICATIONS<\/b><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-27a9eefe e-con-full e-flex e-con e-child\" data-id=\"27a9eefe\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40c6c711 animated-slow elementor-invisible elementor-widget elementor-widget-image\" data-id=\"40c6c711\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1920\" src=\"https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-scaled.jpg\" class=\"attachment-full size-full wp-image-914\" alt=\"\" srcset=\"https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-scaled.jpg 2560w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-300x225.jpg 300w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-1024x768.jpg 1024w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-768x576.jpg 768w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-1536x1152.jpg 1536w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-2048x1536.jpg 2048w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-1200x900.jpg 1200w, https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/Lipo-SIL_SLIKA-1980x1485.jpg 1980w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-340cbed e-con-full animated-slow e-flex elementor-invisible e-con e-parent\" data-id=\"340cbed\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-10fe36d e-con-full e-flex e-con e-child\" data-id=\"10fe36d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0e36885 elementor-widget elementor-widget-text-editor\" data-id=\"0e36885\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>NEWS<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13287a1 elementor-grid-3 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-elementor-blog-posts\" data-id=\"13287a1\" data-element_type=\"widget\" data-settings=\"{&quot;columns&quot;:&quot;3&quot;,&quot;columns_tablet&quot;:&quot;2&quot;,&quot;columns_mobile&quot;:&quot;1&quot;}\" data-widget_type=\"elementor-blog-posts.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"wpcap-grid\">\n\t\t\t\t\t\t<div class=\"wpcap-grid-container elementor-grid wpcap-grid-desktop-3 wpcap-grid-tablet-2 wpcap-grid-mobile-1\">\n\n\t\t\t\t\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Lipo-SIL TITLE: Innovation in the treatment of squamous intraepithelial lesions: development of multicomponent formulations based on alpha-lipoic acid with high bioavailability SIL refers to a precancerous condition that causes significant concern for patients. Currently, there are no specific recommendations for non-invasive therapeutic approaches; however, more frequent check-ups are advised for patients with Low-Grade Squamous Intraepithelial [&hellip;]<\/p>","protected":false},"author":1,"featured_media":877,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-911","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lipo-SIL - Nourish<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nourish.pharma.hr\/hr\/projects\/lipo-sil\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipo-SIL - Nourish\" \/>\n<meta property=\"og:description\" content=\"Lipo-SIL TITLE: Innovation in the treatment of squamous intraepithelial lesions: development of multicomponent formulations based on alpha-lipoic acid with high bioavailability SIL refers to a precancerous condition that causes significant concern for patients. Currently, there are no specific recommendations for non-invasive therapeutic approaches; however, more frequent check-ups are advised for patients with Low-Grade Squamous Intraepithelial [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nourish.pharma.hr\/hr\/projects\/lipo-sil\/\" \/>\n<meta property=\"og:site_name\" content=\"Nourish\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-09T10:48:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-11T11:59:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/lipo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1048\" \/>\n\t<meta property=\"og:image:height\" content=\"584\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Napisao\/la\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Procijenjeno vrijeme \u010ditanja\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"http:\/\/nourish.pharma.hr\/#\/schema\/person\/0c3d8644f700c81d5e1d93f4ae78a169\"},\"headline\":\"Lipo-SIL\",\"datePublished\":\"2024-11-09T10:48:38+00:00\",\"dateModified\":\"2025-01-11T11:59:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/\"},\"wordCount\":445,\"publisher\":{\"@id\":\"http:\/\/nourish.pharma.hr\/#organization\"},\"image\":{\"@id\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/nourish.pharma.hr\/wp-content\/uploads\/2024\/11\/lipo.jpg\",\"articleSection\":[\"Projects\"],\"inLanguage\":\"hr\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/\",\"url\":\"https:\/\/nourish.pharma.hr\/projects\/lipo-sil\/\",\"name\":\"Lipo-SIL - 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