The waste remaining after food production represents economic loss and environmental burden but also an underused source of bioactive components (BCs). ExtracTom-App is focused on developing sustainable processes for the formulation of innovative nutraceuticals using tomato waste (TW) as an available secondary raw material rich in BCs – pectin (P) and carotenoids (C)). It complies with global guidelines for the transition to resource-efficient production. Within the project green extraction procedures for P and C will be developed, using an unexplored combined mechanochemical and microwave extraction (MCE/MAE) – green extraction techniques with satisfactory level of technological readiness. P and C will be utilized in the development of innovative formulations (Se nanoparticles coated with P and inclusion complexes of C), with the aim of improving their stability, bioavailability, biocompatibility, and biological activity (antimicrobial, antioxidant, and anti-inflammatory). Novel green forrmulation approaches will be explored – biogenic synthesis and mechanochemical complexation. Life cycle analysis (LCA), as a scientifically based methodology, will be used to investigate life cycle of tomatoes and the ecological footprint of the newly developed extraction/formulation processes. The results of the project will provide new knowledge about combined MCE/MAE in green extraction of BCs; the potential and limitations of green formulation approaches; and the implementation of LCA in the field of nutraceuticals. In a broader sense, formulation solutions obtained within the project can be adapted to a wider range of biologically active compounds with low stability/bioavailability or narrow therapeutic range. By developing sustainable processes and identifying renewable raw materials that are not in competition with other production chains, it will contribute to the improved sustainability of food production systems.